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An effective half-life of the drug will involve a decay constant that represents the sum of the biological and physical decay constants, as in the formula: = + With the decay constant it is possible to calculate the effective half-life using the formula:
This value is in the denominator of the decay correcting fraction, so it is the same as multiplying the numerator by its inverse (), which is 2.82. (A simple way to check if you are using the decay correct formula right is to put in the value of the half-life in place of "t".
There is a half-life describing any exponential-decay process. For example: As noted above, in radioactive decay the half-life is the length of time after which there is a 50% chance that an atom will have undergone nuclear decay. It varies depending on the atom type and isotope, and is usually determined experimentally. See List of nuclides.
Any one of decay constant, mean lifetime, or half-life is sufficient to characterise the decay. The notation λ for the decay constant is a remnant of the usual notation for an eigenvalue . In this case, λ is the eigenvalue of the negative of the differential operator with N ( t ) as the corresponding eigenfunction .
Sometimes a partial half-life is given, but this term is misleading; due to competing modes, it is not true that half of the particles will decay through a particular decay mode after its partial half-life. The partial half-life is merely an alternate way to specify the partial decay constant λ, the two being related through:
Caesium in the body has a biological half-life of about one to four months. Mercury (as methylmercury) in the body has a half-life of about 65 days. Lead in the blood has a half life of 28–36 days. [29] [30] Lead in bone has a biological half-life of about ten years. Cadmium in bone has a biological half-life of about 30 years.
Half time is the time taken by a quantity to reach one half of its extremal value, where the rate of change is proportional to the difference between the present value and the extremal value (i.e. in exponential decay processes). It is synonymous with half-life, but used in slightly different contexts.
But is also equivalent to divided by elimination rate half-life /, = /. Thus, = /. This means, for example, that an increase in total clearance results in a decrease in elimination rate half-life, provided distribution volume is constant.