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Photodynamic therapy (PDT) is a form of phototherapy involving light and a photosensitizing chemical substance used in conjunction with molecular oxygen to elicit cell death (phototoxicity). [ 1 ] PDT is used in treating acne , wet age-related macular degeneration , psoriasis , and herpes .
Central serous chorioretinopathy (CSC or CSCR), also known as central serous retinopathy (CSR), is an eye disease that causes visual impairment, often temporary, usually in one eye. [ 1 ] [ 2 ] When the disorder is active it is characterized by leakage of fluid under the retina that has a propensity to accumulate under the central macula.
Joan Whitten Miller is a Canadian-American ophthalmologist and scientist who has made notable contributions to the treatment and understanding of eye disorders (particularly diseases of the retina). She is credited for developing photodynamic therapy (PDT) with verteporfin (Visudyne), the first
Side effects include eye aches, dilated pupils, headaches, nearsightedness, or blurred or dimmed vision. ... Photodynamic therapy: Often used in conjunction with Lucentis or Avastin, photodynamic ...
observation, photodynamic therapy, thermal laser, anti-VEGF therapy or combination therapy Polypoidal choroidal vasculopathy (PCV) is an eye disease primarily affecting the choroid . It may cause sudden blurring of vision or a scotoma in the central field of vision .
Verteporfin (trade name Visudyne), a benzoporphyrin derivative, is a medication used as a photosensitizer for photodynamic therapy to eliminate the abnormal blood vessels in the eye associated with conditions such as the wet form of macular degeneration.
These relatively new drugs are injected into the eye. Photodynamic therapy (PDT): A photosensitive drug is ‘activated’ by strong light. Consideration may be given to combined therapy of PDT and anti VEGF. Laser photocoagulation: This is occasionally used unless the CNV is subfoveal (affecting the central or macular part of the vision).
Schematic representation of the mechanism of (a) photopharmacology (b) photodynamic therapy, and (c) optogenetics. The discovery of natural photoreceptors such as rhodopsins in the eye inspired the biomedical and pharmacology research community to engineer light-sensitive proteins for therapeutic applications. [2]