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Meso-zeaxanthin, lutein, and 3R,3′R-zeaxanthin are the main carotenoids in the macula lutea, found in a ratio of 1:1:1, and are collectively referred to as macular pigment (MP). [3] Meso-zeaxanthin is concentrated at the epicentre of the macula, where it accounts for around 50% of MP at this location, with lutein dominating the peripheral macula.
Although there are no reported side effects from taking zeaxanthin supplements, the actual health effects of zeaxanthin and lutein are not proven, [5] [6] [7] and, as of 2018, there is no regulatory approval in the European Union or the United States for health claims about products that contain zeaxanthin.
Lutein (/ ˈ lj uː t i ɪ n,-t iː n /; [2] from Latin luteus meaning "yellow") is a xanthophyll and one of 600 known naturally occurring carotenoids.Lutein is synthesized only by plants, and like other xanthophylls is found in high quantities in green leafy vegetables such as spinach, kale and yellow carrots.
Elevated serum beta-carotene does not necessarily result in carotenosis, but the latter is likely to show up when intake is more than 20 mg/day. Average adult intake in the U.S. around 2.3 mg/day. One medium-sized carrot has about 4.0 mg. [citation needed] Carotenoderma can be divided into two major types, primary and secondary.
Nausea is one of the most frequently reported side effects when starting a GLP-1 medication, due to slowed-down digestion. Nausea may be related to overeating while taking these medications as well.
In the AREDS-2 formulation, lutein (10 mg) and zeaxanthin (2 mg) replaced beta-carotene due to the risk of lung cancer in smokers taking beta-carotene. [2] There is some evidence to indicate that people with bilateral early or intermediate AMD, or intermediate AMD in one eye and advanced AMD in the other eye may benefit from vitamin and mineral ...