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Various approaches for HIV vaccine development. The SAV001-H vaccine is considered to be the first whole killed genetically modified HIV-1 vaccine.. According to Dr. Kang, the HIV-1 strain was genetically engineered such that first, “the gene responsible for pathogenicity, known as nef” is removed to make it non-pathogenic.
In 2016, results were published of the first Phase I human clinical trial of a killed whole-HIV-1 vaccine, SAV001. HIV used in the vaccine was chemically and physically deadened through radiation. The trial, conducted in Canada in 2012, demonstrated a good safety profile and elicited antibodies to HIV-1. [21]
The vaccines were developed for HIV subtypes A, B and C by the Vaccine Research Center at the National Institutes of Health (NIH). In April 2013, the data and safety monitoring board recommended stopping vaccinations because there was no evidence that the vaccines could prevent people from getting HIV. The vaccines could also not treat HIV.
In an interview with Yahoo News, Dr. Anthony Fauci discussed the state of HIV vaccine research after the recent failure of a late-stage trial funded by the National Institute of Allergy and ...
This is a timeline of HIV/AIDS, including but not limited to cases before 1980. Pre-1980s See also: Timeline of early HIV/AIDS cases Researchers estimate that some time in the early 20th century, a form of Simian immunodeficiency virus found in chimpanzees (SIVcpz) first entered humans in Central Africa and began circulating in Léopoldville (modern-day Kinshasa) by the 1920s. This gave rise ...
The critical problem that has bedeviled HIV vaccine research for decades, Fauci noted, is a crucial weakness that the virus already successfully exploits: The natural immune response to infection ...
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