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Micro-mass cultures of C3H-10T1/2 cells at varied oxygen tensions stained with Alcian blue. A commonly applied definition of tissue engineering, as stated by Langer [3] and Vacanti, [4] is "an interdisciplinary field that applies the principles of engineering and life sciences toward the development of biological substitutes that restore, maintain, or improve [Biological tissue] function or a ...
The company works in regenerative medicine, in which it owns several extracellular matrix patents. [1] ACell develops, manufactures and markets products for medical and veterinary applications. [ 2 ] The company was founded by Alan R. Spievack, a former associate professor at Harvard Medical School and is currently run by Patrick A. McBrayer.
Autograft: graft taken from one part of the body of an individual and transplanted onto another site in the same individual, e.g., skin graft. Isograft: graft taken from one individual and placed on another individual of the same genetic constitution, e.g., grafts between identical twins.
Acellular dermis is a type of biomaterial derived from processing human or animal tissues to remove cells and retain portions of the extracellular matrix (ECM). These materials are typically cell-free, distinguishing them from classical allografts and xenografts, can be integrated or incorporated into the body, and have been FDA approved for human use for more than 10 years in a wide range of ...
A free gingival graft is a type of gingival grafting performed to correct acquired deficiencies of the gum tissue around teeth or dental implants. Besides autologous tissues, xenogeneic collagen matrices are using for gingival augmentation after dental implantation. [ 1 ]
A decellularized aortic homograft. Decellularization (also spelled decellularisation in British English) is the process used in biomedical engineering to isolate the extracellular matrix (ECM) of a tissue from its inhabiting cells, leaving an ECM scaffold of the original tissue, which can be used in artificial organ and tissue regeneration.
Others, including Broome and Taggert [4] and Donn [5] also described the use of SECT grafts for increasing the zone of keratinized tissue. Of the various ways of preparing the graft recipient site, Edel described using two vertical incisions, mesial and distal to the teeth at which the zone of keratinized tissue was intended to be widened. [1]
Ovine forestomach matrix (OFM), marketed as AROA ECM, is a layer of decellularized extracellular matrix (ECM) biomaterial isolated from the propria submucosa of the rumen of sheep. [ 1 ] [ 2 ] OFM is used in tissue engineering and as a tissue scaffold for wound healing and surgical applications.