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The disease remains progressive and fatal. [11] [12] Patients are managed according to what areas of the body are affected at a particular time. Enzymes, amino acids, antioxidants and vitamins have been used. Treatment for MELAS currently is 1. support the good mitochondria that is left with a mito cocktail and 2. avoid known mito toxins.
Between 40-90% of MELAS syndrome patients are reported to develop dementia, and epilepsy is seen in 71-96% of cases. Additional neurological symptoms reported include recurring headaches, developmental delay, learning disorders, myoclonus, ataxia, and altered mental status. [4]
MELAS is a rare mitochondrial disorder known to affect many parts of the body, especially the nervous system and the brain. Symptoms of MELAS include recurrent severe headaches , muscle weakness ( myopathy ), hearing loss , stroke -like episodes with a loss of consciousness , seizures , and other problems affecting the nervous system . [ 6 ]
Mitochondrial disease is a group of disorders caused by mitochondrial dysfunction. ... MELAS syndrome, mitochondrial encephalopathy, lactic acidosis, ...
MELAS syndrome may also be accompanied by another mitochondrial disorder called myoclonic epilepsy with ragged-red fibers, also known as MERRF syndrome. [9] In addition to symptoms of MELAS syndrome, additional signs and symptoms may include muscle twitches (), difficulty coordinating movement (), and abnormal muscle cells known as ragged-red fibers.
Mitochondrial myopathies are types of myopathies associated with mitochondrial disease. [1] Adenosine triphosphate (), the chemical used to provide energy for the cell, cannot be produced sufficiently by oxidative phosphorylation when the mitochondrion is either damaged or missing necessary enzymes or transport proteins.
Includes Mitochondrial Encephalitis Lactic Acidosis Seizures (MELAS), myoclonic epilepsy and ragged red fibers (MERRF), maternally inherited Leigh syndrome (MILS), and mitochondrial neurograstrointestinal encephalomyopathy (MNGIE), all of which can all develop optic neuropathies, although it is usually a secondary feature overshadowed by more ...
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