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Silicone sheets and gels Dr. Turegano says silicone sheets and gels, which you can buy at your pharmacy and certain retail outlets, can reduce the size, color, and texture of keloids.
The exact mechanism of action of silicone gel sheeting has not been fully studied. Currently, many proposed mechanisms explain the efficacy of such treatment, including the occlusion and hydration effect, increased body surface temperature, polarized electric charge, immunological effects, etc. [9] The occlusion and hydration effect is the most studied mechanism of action.
A hypertrophic scar is a cutaneous condition characterized by deposits of excessive amounts of collagen which gives rise to a raised scar, but not to the degree observed with keloids. [1] Like keloids, they form most often at the sites of pimples, body piercings, cuts and burns. They often contain nerves and blood vessels.
Another 2022 systematic review compared silicone gel sheeting with no treatment, treatment with non-silicone gel sheeting and treatment with intralesional injections of triamcinolone acetonide. The authors only found two small studies (36 participants in total) that compared these treatment options so were unable to determine which (if any) was ...
A study conducted by the Catholic University of Korea concluded that verapamil-releasing silicone gel is effective and is a superior alternative to the conventional silicone gel where decreased median SEI, fibroblast count, and collagen density in all verapamil-added treatment groups were observed.
Keloids can also form inside the body. After spinal surgery, a Keloid can form around the nerve roots, leading to "failed back surgery" syndrome. The Keloid can continue to grow for as long as 18 months post-operatively. In some cases, the scar tissue is so dense that the nerve roots can no longer be observed in an MRI.