Search results
Results From The WOW.Com Content Network
[1] [5] Animal intermediate filaments are subcategorized into six types based on similarities in amino acid sequence and protein structure. [6] Most types are cytoplasmic, but one type, Type V is a nuclear lamin. Unlike microtubules, IF distribution in cells shows no good correlation with the distribution of either mitochondria or endoplasmic ...
Some animals like the fruit fly do not have any cytoplasmic intermediate filaments. In those animals that express cytoplasmic intermediate filaments, these are tissue specific. [5] Keratin intermediate filaments in epithelial cells provide protection for different mechanical stresses the skin may endure. They also provide protection for organs ...
Intermediate filaments composed of keratin or desmin are attached to membrane-associated attachment proteins that form a dense plaque on the cytoplasmic face of the membrane. Cadherin molecules form the actual anchor by attaching to the cytoplasmic plaque, extending through the membrane and binding strongly to cadherins coming through the ...
It is composed of intermediate filaments and membrane associated proteins. Besides providing mechanical support, the nuclear lamina regulates important cellular events such as DNA replication and cell division. Additionally, it participates in chromatin organization and it anchors the nuclear pore complexes embedded in the nuclear envelope.
Type 1 and 2 intermediate filaments are those that are composed of keratins, and they are mainly found in epithelial cells. Type 3 intermediate filaments contain vimentin. They can be found in a variety of cells which include smooth muscle cells, fibroblasts, and white blood cells. Type 4 intermediate filaments are the neurofilaments found in ...
The structure of lamins is composed of three units that are common among intermediate filaments: a central α-helical rod domain containing heptad repeats surrounded by globular N and C-terminal domains. The N-terminal is shorter and located at the top (head) while the C-terminal is longer and located at the end (tail).
The protein composition of neurofilaments varies widely across different animal phyla. Most is known about mammalian neurofilaments. Historically, mammalian neurofilaments were originally thought to be composed of just three proteins called neurofilament protein NF-L (low molecular weight; NF-L), NF-M (medium molecular weight; NF-M) and NF-H (high molecular weight; NF-H).
Vimentin is a type III intermediate filament (IF) protein that is expressed in mesenchymal cells. IF proteins are found in all animal cells [ 6 ] as well as bacteria . [ 7 ] Intermediate filaments, along with tubulin -based microtubules and actin -based microfilaments , comprises the cytoskeleton .