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Adrenal insufficiency is a condition in which the adrenal glands do not produce adequate amounts of steroid hormones. The adrenal glands—also referred to as the adrenal cortex—normally secrete glucocorticoids (primarily cortisol), mineralocorticoids (primarily aldosterone), and androgens.
An important aspect of management of nonclassic CAH is suppression of central precocious puberty if it has begun. The usual clues to central puberty in boys are that the testes are pubertal in size, or that androgens of adrenal origin remain elevated even when the 17OHP has been reduced toward normal. In girls central puberty is less often a ...
Adrenal crisis, also known as Addisonian crisis or acute adrenal insufficiency, is a life-threatening complication of adrenal insufficiency. Hypotension and hypovolemic shock are the main symptoms of an adrenal crisis. Other symptoms include weakness, anorexia, nausea, vomiting, fever, fatigue, abnormal electrolytes, confusion, and coma.
Rapid onset of symptoms indicates acute adrenal failure, which is a clinical emergency. [5] An adrenal crisis can be triggered by stress, such as from an injury, surgery, or infection. [1] Addison's disease arises when the adrenal gland does not produce sufficient amounts of the steroid hormones cortisol and (sometimes) aldosterone. [1]
Airedale NHS Foundation Trust, established 1 November 1991 as Airedale NHS Trust, [2] authorised as a foundation trust on 1 June 2010. [3]Alder Hey Children's NHS Foundation Trust, established 21 December 1990 as Royal Liverpool Children's Hospital and Community Services NHS Trust, [4] changed its name to The Royal Liverpool Children's National Health Service Trust on 15 March 1996, [5 ...
Glucocorticoid deficiency can be caused by inherited genetic disorders that affect the production of cortisol in the adrenal glands, such as familial glucocorticoid deficiency (FGD). [3] FGD is a group of monogenic recessive disorders caused by disease-causing variants in genes involved in cortisol biosynthesis. [ 4 ]
With prolonged suppression, the adrenal glands atrophy (physically shrink), and can take months to recover full function after discontinuation of the exogenous glucocorticoid. During this recovery time, the patient is vulnerable to adrenal insufficiency during times of stress, such as illness. While suppressive dose and time for adrenal ...
Two slices of an adrenal gland with a cortical adenoma, from a person with Conn's syndrome. The condition is due to: [14] Bilateral idiopathic (micronodular) adrenal hyperplasia: 66% of cases [1] Adrenal adenoma (Conn's disease): 33% of cases [1] Primary (unilateral) adrenal hyperplasia: 2% of cases