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Bst1 (Bone marrow stromal cell antigen 1, ADP-ribosyl cyclase 2, CD157) is an enzyme that in humans is encoded by the BST1 gene. [5] [6] [7] CD157 is a paralog of CD38, both of which are located on chromosome 4 (4p15) in humans. [8] Bst1 is a stromal cell line-derived glycosylphosphatidylinositol-anchored molecule that facilitates pre-B-cell ...
Stromal cells, or mesenchymal stromal cells, are differentiating cells found in abundance within bone marrow but can also be seen all around the body. Stromal cells can become connective tissue cells of any organ , for example in the uterine mucosa ( endometrium ), prostate , bone marrow , lymph node and the ovary .
The most commonly used source of MSC's is bone marrow aspirate. Most of the adult bone marrow consists of blood cells in various stages of differentiation. [10] These marrow components can be divided into plasma, red blood cells, platelets, and nucleated cells. The adult stem cell fraction is present in the nucleated cells of the marrow.
The ratio between myeloid series and erythroid cells is relevant to bone marrow function, and also to diseases of the bone marrow and peripheral blood, such as leukemia and anemia. The normal myeloid-to-erythroid ratio is around 3:1; this ratio may increase in myelogenous leukemias , decrease in polycythemias , and reverse in cases of thalassemia .
The ECM surrounding brain, muscle and bone tissues range from soft to stiff. The transduction of the stem cells into these cells types is not directed solely by chemokine cues and cell to cell signaling. The elasticity of the microenvironment can also affect the differentiation of mesenchymal stem cells (MSCs which originate in bone marrow.)
17311 Ensembl ENSG00000049130 ENSMUSG00000019966 UniProt P21583 P20826 RefSeq (mRNA) NM_003994 NM_000899 NM_013598 NM_001347156 RefSeq (protein) NP_000890 NP_003985 NP_001334085 NP_038626 Location (UCSC) Chr 12: 88.49 – 88.58 Mb Chr 10: 99.85 – 99.94 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Stem cell factor (also known as SCF, KIT-ligand, KL, or steel factor) is a cytokine ...
Parietal epithelial cell (PEC) Podocyte; Angioblast → Endothelial cell; Mesangial cell. Intraglomerular; Extraglomerular; Juxtaglomerular cell; Macula densa cell; Stromal cell → Interstitial cell → Telocytes; Kidney proximal tubule brush border cell; Kidney distal tubule cell; Connecting tubule cells; α-intercalated cell; β-intercalated ...
Mesenchymal cells, on the other hand, lack this polarization, have a spindle-shaped morphology and interact with each other only through focal points. [4] Epithelial cells express high levels of E-cadherin, whereas mesenchymal cells express those of N-cadherin, fibronectin and vimentin. Thus, EMT entails profound morphological and phenotypic ...