Search results
Results From The WOW.Com Content Network
Alcohol can exacerbate the symptoms and may directly contribute to increased severity of symptoms. The reasons for toxicity vary depending on the mixture of drugs. Usually, most victims die after using two or more drugs in combination that suppress breathing, and the low blood oxygen level causes brain death .
The more alcohol and alprazolam taken, the worse the interaction. [38] Combination of alprazolam with the herb kava can result in the development of a semi- comatose state. [ 57 ] Plants in the genus Hypericum , including St. John's wort , conversely can lower the plasma levels of alprazolam and reduce its therapeutic effect.
Alcohol: Cannabis: Tincture of cannabis. Herb and Al. Judgement Day Cross fading, twisting, getting twisted [13] Called Judgement Day in Ghana when cannabis is added to the drink Alcohol: Cocaine: Snow-cone Snow-coning Ethanol is metabolized into cocaethylene [14] Alcohol: MDMA: Tipsy flip Tipsy flipping It may be dangerous Alcohol: Nicotine ...
Interactions with other drugs, food and drink, and other factors may increase or decrease the effect of certain analgesics and alter their half-life. Because some listed analgesics are prodrugs or have active metabolites, individual variation in liver enzymes (e.g., CYP2D6 enzyme) may result in significantly altered effects.
Cross-tolerance is a phenomenon that occurs when tolerance to the effects of a certain drug produces tolerance to another drug. It often happens between two drugs with similar functions or effects—for example, acting on the same cell receptor or affecting the transmission of certain neurotransmitters.
Oxycodone, a semi-synthetic opioid, is a highly selective full agonist of the μ-opioid receptor (MOR). [41] [42] This is the main biological target of the endogenous opioid neuropeptide β-endorphin. [19] Oxycodone has low affinity for the δ-opioid receptor (DOR) and the κ-opioid receptor (KOR), where it is an agonist similarly.
The most common symptoms of overdose include central nervous system (CNS) depression, impaired balance, ataxia, and slurred speech. Severe symptoms include coma and respiratory depression. Supportive care is the mainstay of treatment of benzodiazepine overdose. There is an antidote, flumazenil, but its use is controversial. [2]
Opioid overdoses are diagnosed based on symptoms and examination. [3] Risk factors for opioid overdose include high levels of opioid dependence , use of opioids via injection, high dosed opioid usage, having a mental disorder or having a predisposition for one, and use of opioids in combination with other substances, such as alcohol ...