Ads
related to: neural activity models for autism
Search results
Results From The WOW.Com Content Network
Another goal of the use of rodent models to study autism is to identify the mechanism by which autism develops in humans. [1] Other researchers have developed an autism severity score to measure the degree of severity of the mice's autism, as well as the use of scent marking behavior [21] and vocalization distress [14] as models for communication.
Activity-dependent plasticity is a form of functional and structural neuroplasticity that arises from the use of cognitive functions and personal experience. [ 1 ] Hence, it is the biological basis for learning and the formation of new memories .
Autism spectrum disorder [a] (ASD), or simply autism, is a neurodevelopmental disorder "characterized by persistent deficits in social communication and social interaction across multiple contexts" and "restricted, repetitive patterns of behavior, interests, or activities". [11] Sensory abnormalities are also included in the diagnostic manuals ...
The underconnectivity theory of autism posits that autistic people tend to have fewer high-level neural connections and less global synchronization, along with an excess of low-level processes. [31] Functional connectivity studies have found both hypo- and hyperconnectivity in brains of autistic people. [ 32 ]
Activity-dependent mechanisms influence neural circuit development and are crucial for laying out early connectivity maps and the continued refinement of synapses which occurs during development. [41] There are two distinct types of neural activity we observe in developing circuits -early spontaneous activity and sensory-evoked activity.
A neural network is a group of interconnected units called neurons that send signals to one another. Neurons can be either biological cells or mathematical models . While individual neurons are simple, many of them together in a network can perform complex tasks.
However, because of the multigene involvement in autism, the MECP2 gene has only been identified as a vulnerability factor in autism. [63] The most current model illustrating MECP2 is known as the transcriptional activator model. Another potential molecular convergence involves the early growth response gene-2 (EGR2). [60]
Pierce developed the Get SET Early Model to standardize early autism screening, evaluation, and treatment in medical settings. The program connects three key steps: Screening (S), Evaluation (E), and Treatment (T), aiming to detect ASD by age two. Early diagnosis allows children to start treatment early, benefiting from neural plasticity.