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  2. DNA-binding domain - Wikipedia

    en.wikipedia.org/wiki/DNA-binding_domain

    The regulatory domain binds an allosteric effector molecule (green). The allosteric response of the protein is communicated from the regulatory domain to the DNA binding domain through the linker region. [2] One or more DNA-binding domains are often part of a larger protein consisting of further protein domains with differing function. The ...

  3. Activator (genetics) - Wikipedia

    en.wikipedia.org/wiki/Activator_(genetics)

    Activator proteins consist of two main domains: a DNA-binding domain that binds to a DNA sequence specific to the activator, and an activation domain that functions to increase gene transcription by interacting with other molecules. [1]

  4. Binding domain - Wikipedia

    en.wikipedia.org/wiki/Binding_domain

    In molecular biology, binding domain is a protein domain which binds to a specific atom or molecule, such as calcium or DNA. A protein domain is a part of a protein sequence and a tertiary structure that can change or evolve, function, and live by itself independent of the rest of the protein chain. [1] Upon binding, proteins may undergo a ...

  5. DNA-binding protein - Wikipedia

    en.wikipedia.org/wiki/DNA-binding_protein

    DNA-binding proteins are proteins that have DNA-binding domains and thus have a specific or general affinity for single- or double-stranded DNA. [ 3 ] [ 4 ] [ 5 ] Sequence-specific DNA-binding proteins generally interact with the major groove of B-DNA , because it exposes more functional groups that identify a base pair .

  6. Transcription activator-like effector nuclease - Wikipedia

    en.wikipedia.org/wiki/Transcription_activator...

    The FokI domain functions as a dimer, requiring two constructs with unique DNA binding domains for sites in the target genome with proper orientation and spacing. Both the number of amino acid residues between the TALE DNA binding domain and the FokI cleavage domain and the number of bases between the two individual TALEN binding sites appear ...

  7. DNA binding site - Wikipedia

    en.wikipedia.org/wiki/DNA_binding_site

    DNA contacts of different types of DNA-binding domains. DNA binding sites are a type of binding site found in DNA where other molecules may bind. DNA binding sites are distinct from other binding sites in that (1) they are part of a DNA sequence (e.g. a genome) and (2) they are bound by DNA-binding proteins.

  8. bZIP domain - Wikipedia

    en.wikipedia.org/wiki/BZIP_domain

    One part of the domain contains a region that mediates sequence specific DNA binding properties and the leucine zipper that is required to hold together (dimerize) two DNA binding regions. The DNA binding region comprises a number of basic amino acids such as arginine and lysine. Proteins containing this domain are transcription factors. [1] [2]

  9. HMG-box - Wikipedia

    en.wikipedia.org/wiki/HMG-box

    The domain is composed of approximately 75 amino acid residues that collectively mediate the DNA-binding of chromatin-associated high-mobility group proteins. HMG-boxes are present in many transcription factors and chromatin-remodeling complexes, where they can mediate non-sequence or sequence-specific DNA binding. [2]