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Barrett's esophagus is a condition in which there is an abnormal (metaplastic) change in the mucosal cells lining the lower portion of the esophagus, from stratified squamous epithelium to simple columnar epithelium with interspersed goblet cells that are normally present only in the small intestine and large intestine.
Intestinal metaplasia is the transformation of epithelium (usually of the stomach or the esophagus) into a type of epithelium resembling that found in the intestine.In the esophagus, this is called Barrett's esophagus.
In gastrointestinal endoscopy, narrow-band imaging has found use in the identification of Barrett's esophagus, [3] in the identification of pit patterns to classify colorectal polyps and tumours, [4] and in the identification of atypical dysplastic cells in the colon of patients with ulcerative colitis. [5]
Left untreated, Barrett's esophagus, a precancerous condition of the esophageal lining, can lead to life-threatening cancer of the esophagus.
Some people also experience a sensation known as globus esophagus, where it feels as if a ball is lodged in the lower part of the esophagus. The following are additional diseases and conditions that affect the esophagus: Achalasia [1] Acute esophageal necrosis; Barrett's esophagus; Boerhaave syndrome; Caustic injury to the esophagus; Chagas disease
He is also the leader of Barrett's esophagus study group; a global consortium of 7 academic institutions. [15] He has developed a registry of patients with Barrett's esophagus, dysplasia and cancer prospectively followed at each of these centers to study the natural history, health care utilization, and evaluate factors associated with progression.
People with Barrett's esophagus (a change in the cells lining the lower esophagus) are at much higher risk, [55] and may receive regular endoscopic screening for the early signs of cancer. [56] Because the benefit of screening for adenocarcinoma in people without symptoms is unclear, [2] it is not recommended in the United States. [1]
Esophageal strictures – the persistent narrowing of the esophagus caused by reflux-induced inflammation; Barrett's esophagus – intestinal metaplasia (changes of the epithelial cells from squamous to intestinal columnar epithelium) of the distal esophagus [20] Esophageal adenocarcinoma – a form of cancer [17]