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A fibroblast is a type of biological cell typically with a spindle shape [1] that synthesizes the extracellular matrix and collagen, [2] produces the structural ...
This type of connective tissue is found mostly in the reticular layer (or deep layer) of the dermis. [3] It is also in the sclera and in the deeper skin layers. Due to high portions of collagenous fibers, dense irregular connective tissue provides strength, making the skin resistant to tearing by stretching forces from different directions.
Fibroblasts are widely dispersed in this tissue; they are irregular branching cells that secrete strong fibrous proteins and proteoglycans as an extracellular matrix. The cells of this type of tissue are generally connected by a gelatinous substance known as ground substance primarily made up of collagenous and elastic fibers.
Crowded between the collagen fibers are rows of fibroblasts, fiber-forming cells, that generate the fibers. Dense connective tissue forms strong, rope-like structures such as tendons and ligaments. Tendons attach skeletal muscles to bones; ligaments connect bones to bones at joints.
Reticular connective tissue resembles areolar connective tissue, but the only fibers in its matrix are reticular fibers, which form a delicate network along which fibroblasts called reticular cells lie scattered. Although reticular fibers are widely distributed in the body, reticular tissue is limited to certain sites.
The cross-talk between the host stroma and tumor cells is essential for tumor growth and progression. Tumor stromal production exhibits similar qualities as normal wound repair such as new blood vessel formation, immune cell and fibroblast infiltration, and considerable remodeling of the extracellular matrix.
Loose connective tissue fibroblasts: Corneal fibroblasts (corneal keratocytes) Tendon fibroblasts: Bone marrow reticular tissue fibroblasts: Other nonepithelial fibroblasts: Hepatic stellate cell (Ito cell) liver Pericyte: Nucleus pulposus cell: intervertebral disc: Hyaline cartilage chondrocyte: Fibrocartilage chondrocyte: Elastic cartilage ...
The fibroblast-like synoviocytes (derived from mesenchyme) [3] manufacture a long-chain sugar polymer called hyaluronan (hence rich in endoplasmic reticulum); which makes the synovial fluid "ropy"-like egg-white, together with a molecule called lubricin, which lubricates the joint surfaces. The water of synovial fluid is not secreted as such ...