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  2. Dimethylacetamide - Wikipedia

    en.wikipedia.org/wiki/Dimethylacetamide

    The chemical reactions of dimethylacetamide are typical of N,N-disubstituted amides. Hydrolysis of the acyl-N bond occurs in the presence of acids: CH 3 CON(CH 3) 2 + H 2 O + HCl → CH 3 COOH + (CH 3) 2 NH 2 + Cl −. However, it is resistant to bases. For this reason DMA is a useful solvent for reactions involving strong bases such as sodium ...

  3. Hydroxylamine - Wikipedia

    en.wikipedia.org/wiki/Hydroxylamine

    Hydroxylamine derivatives substituted in place of the hydroxyl or amine hydrogen are (respectively) called O- or N‑hydroxyl­amines. In general N‑hydroxyl­amines are more common. Examples are N‑tert‑butyl­hydroxyl­amine or the glycosidic bond in calicheamicin. N,O‑Dimethyl­hydroxylamine is a precursor to Weinreb amides.

  4. Weerman degradation - Wikipedia

    en.wikipedia.org/wiki/Weerman_degradation

    At first the carbonic acid amide (1) reacts with the sodium hypochlorite. After the separation of water and chloride an amine with a free bond is built 2. The intermediate (3) is generated by rearrangement. In the next step a hydrolysis takes place. Water is added at the carbon-atom with the number '1'. A hydroxylic group is generated.

  5. Hofmann rearrangement - Wikipedia

    en.wikipedia.org/wiki/Hofmann_rearrangement

    Base abstraction of the remaining amide proton gives a bromoamide anion. The bromoamide anion rearranges as the R group attached to the carbonyl carbon migrates to nitrogen at the same time the bromide ion leaves, giving an isocyanate. The isocyanate adds water in a nucleophilic addition step to yield a carbamic acid (aka urethane).

  6. Propanamide - Wikipedia

    en.wikipedia.org/wiki/Propanamide

    It is the amide of propanoic acid. This organic compound is a mono-substituted amide. [2] Organic compounds of the amide group can react in many different organic processes to form other useful compounds for synthesis.

  7. 2-Pyridone - Wikipedia

    en.wikipedia.org/wiki/2-Pyridone

    The amide group can be involved in hydrogen bonding to other nitrogen- and oxygen-containing species.. The predominant solid state form is 2-pyridone. This has been confirmed by X-ray crystallography which shows that the hydrogen in solid state is closer to the nitrogen than to the oxygen (because of the low electron density at the hydrogen the exact positioning is difficult), and IR ...

  8. Diketene - Wikipedia

    en.wikipedia.org/wiki/Diketene

    Diketene readily hydrolyzes in water forming acetoacetic acid. Its half-life in water is approximately 45 min. a 25 °C at 2 < pH < 7. [4] Certain diketenes with two aliphatic chains, such as alkyl ketene dimers (AKDs), are used industrially to improve hydrophobicity in paper. At one time acetic anhydride was prepared by the reaction of ketene ...

  9. Schmidt reaction - Wikipedia

    en.wikipedia.org/wiki/Schmidt_reaction

    Attack by water converts 6 to protonated imidic acid 7, which undergoes loss of proton to arrive at the imidic acid tautomer of the final amide. In an alternative mechanism, the migration occurs at 9, directly after protonation of intermediate 3, in a manner similar to the Baeyer–Villiger oxidation to give protonated amide 10. Loss of a ...