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Rosuvastatin, sold under the brand name Crestor among others, is a statin medication, used to prevent cardiovascular disease in those at high risk and treat abnormal lipids. [6] It is recommended to be used together with dietary changes, exercise, and weight loss. [ 6 ]
2 – 4 No NA Simvastatin 26 – 47 8 – 16 12 – 34 19 – 36 CYP3A4 95 – 98 1 – 3 No 11 Fluvastatin 22 – 36 3 – 11 12 – 25 16 – 27 CYP2C9 98 0,5 – 3,0 No 28 Rosuvastatin 45 – 63 8 – 14 10 – 35 33 – 46 CYP2C9 88 19 Yes 5 Pravastatin 22 – 34 2 – 12 15 – 24 16 – 25 Sulfation 43 – 67 2 – 3 Yes 44
The incidence of rhabdomyolysis was 0.44 per 10,000 patients treated with statins other than cerivastatin. However, the risk was over 10-fold greater if cerivastatin was used, or if the standard statins (atorvastatin, fluvastatin, lovastatin, pravastatin, or simvastatin) were combined with a fibrate (fenofibrate or gemfibrozil) treatment ...
AstraZeneca's (NYS: ANZ) press release on the SATURN trial is an object lesson in how to spin a study that didn't turn out as expected: Focus on the positive. The company announced SATURN showed ...
AstraZeneca (NYS: AZN) just lost a potential marketing edge for Crestor. In trial results announced today, the statin drug failed to best Lipitor at clearing clogged arteries, at least in a ...
For this observational study, researchers analyzed data from the U.K. Biobank and Whitehall II study of more than 20,000 adults in the U.K. 70 years and older with or without previous ...