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Forward genetics provides an unbiased approach because it relies heavily on identifying the genes or genetic factors that cause a particular phenotype or trait of interest. [ 1 ] This was initially done by using naturally occurring mutations or inducing mutants with radiation, chemicals, or insertional mutagenesis (e.g. transposable elements ).
These tools perform normalization and calculate the abundance of each gene expressed in a sample. [51] RPKM, FPKM and TPMs [52] are some of the units employed to quantification of expression. Some software are also designed to study the variability of genetic expression between samples (differential expression).
Gene redundancy is the existence of multiple genes in the genome of an organism that perform the same function. Gene redundancy can result from gene duplication . [ 1 ] Such duplication events are responsible for many sets of paralogous genes. [ 1 ]
Forward genetics (or a forward genetic screen) starts with a phenotype and then attempts to identify the causative mutation and thus gene(s) responsible for the phenotype. For instance, the famous screen by Christiane Nüsslein-Volhard and Eric Wieschaus mutagenized fruit flies and then set out to find the genes causing the observed mutant ...
Genetic redundancy is a term typically used to describe situations where a given biochemical function is redundantly encoded by two or more genes. In these cases, mutations (or defects) in one of these genes will have a smaller effect on the fitness of the organism than expected from the genes’ function.
Minimum redundancy feature selection is an algorithm frequently used in a method to accurately identify characteristics of genes and phenotypes and narrow down their relevance and is usually described in its pairing with relevant feature selection as Minimum Redundancy Maximum Relevance (mRMR).
The VISTA family of tools is developed and hosted at the Genomics Division of Lawrence Berkeley National Laboratory.This collaborative effort is supported by the Programs for Genomic Applications grant from the NHLBI/NIH and the Office of Biological and Environmental Research, Office of Science, US Department of Energy.
Reverse genetics is a method in molecular genetics that is used to help understand the function(s) of a gene by analysing the phenotypic effects caused by genetically engineering specific nucleic acid sequences within the gene. The process proceeds in the opposite direction to forward genetic screens of classical genetics.