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Multiple sclerosis is typically diagnosed based on the presenting signs and symptoms, in combination with supporting medical imaging and laboratory testing. [4] It can be difficult to confirm, especially early on, since the signs and symptoms may be similar to those of other medical problems. [5] [6]
Diagnosis of MS has always been made by clinical examination, supported by MRI or CSF tests. According with both the pure autoimmune hypothesis and the immune-mediated hypothesis, [5] researchers expect to find biomarkers able to yield a better diagnosis, and able to predict the response to the different available treatments. [6]
The McDonald criteria maintained a scheme for diagnosing MS based solely on clinical grounds but also proposed for the first time that when clinical evidence is lacking, magnetic resonance imaging (MRI) findings can serve as surrogates for dissemination in space (DIS) and/or time (DIT) to diagnose MS. [5] The criteria try to prove the existence ...
Furthermore, the presence of autism can make it harder to diagnose coexisting psychiatric disorders such as depression. [9] Diagnosing will be much harder in adults, since most people with ASD who reach adulthood undiagnosed, learn diverse (and often intense) masking techniques which make external diagnosis almost impossible.
A new study finds that in about one in 10 cases of multiple sclerosis, the body makes a distinct set of antibodies years before symptoms emerge. (Getty Images) (Md Babul Hosen via Getty Images)
Distinguishing between ASD and other diagnoses can be challenging because the traits of ASD often overlap with symptoms of other disorders, and the characteristics of ASD make traditional diagnostic procedures difficult. [2] [3] Autism is associated with several genetic disorders, [4] perhaps due to an overlap in genetic causes. [5]
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