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Symptoms may recur and treatment for some days may be necessary. Catatonia due to abrupt or overly rapid withdrawal from benzodiazepines, as part of the benzodiazepine withdrawal syndrome, should also respond to lorazepam treatment. [55] As lorazepam can have paradoxical effects, haloperidol is sometimes given at the same time. [54] [56]
A paradoxical reaction (or paradoxical effect) is an effect of a chemical substance, such as a medical drug, that is opposite to what would usually be expected. An example of a paradoxical reaction is pain caused by a pain relief medication .
Response to lorazepam can support the diagnosis of catatonia and inform treatment strategy, although a minority may not respond to the challenge. [3] The lorazepam challenge can elicit a false positive result when administered to patients afflicted with conditions that can sometimes mimic catatonia, such as benzodiazepine and alcohol withdrawal.
Paradoxical reactions are rare in the general population, with an incidence rate below 1% and similar to placebo. [ 8 ] [ 120 ] However, they occur with greater frequency in recreational abusers, individuals with borderline personality disorder , children, and patients on high-dosage regimes.
Paradoxical disinhibition is a paradoxical reaction, an uncommon but recognized phenomenon, characterized by acute excitement and an altered mental state, caused by benzodiazepines. The mechanism is poorly known, but the most accepted theory is that it occurs secondary to inhibition of the restraining influences of the cortex and frontal lobe ...
For the first time in two decades, the Food and Drug Administration (FDA) has approved a new class of medication that provides an alternative to addictive opioids for patients looking to manage ...
These effects are paradoxical to the use of benzodiazepines, both clinically and non-medically, in management of mental health conditions. [44] [45] Long-term benzodiazepine use may lead to the creation or exacerbation of physical and mental health conditions, which improve after six or more months of abstinence.
This is a complete list of clinically approved prescription antidepressants throughout the world, as well as clinically approved prescription drugs used to augment antidepressants or mood stabilizers, by pharmacological and/or structural classification. Chemical/generic names are listed first, with brand names in parentheses.