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Levofloxacin was patented in 1985 and approved for medical use in the United States in 1996. [7] [10] It is on the World Health Organization's List of Essential Medicines. [11] It is available as a generic medication. [7] In 2022, it was the 251st most commonly prescribed medication in the United States, with more than 1 million prescriptions ...
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β-Lactam antibiotics are indicated for the prevention and treatment of bacterial infections caused by susceptible organisms. At first, β-lactam antibiotics were mainly active only against gram-positive bacteria, yet the recent development of broad-spectrum β-lactam antibiotics active against various gram-negative organisms has increased their usefulness.
PPI (standard dose) bid, tetracycline 0.5 g qid, metronidazole 0.25 g qid and bismuth standard dose qid First line or second line therapy Levofloxacin-based triple therapy 10 PPI (standard dose) bid, levofloxacin 0.5 g qd and amoxicillin 1 g bid Second line therapy if there is no fluoroquinolone resistance Culture-guided therapy 10
Ofloxacin is a racemic mixture, which consists of 50% levofloxacin (the biologically active component) and 50% of its “mirror image” or enantiomer dextrofloxacin. [52] "After multiple-dose administration of 200 mg and 300 mg doses, peak serum levels of 2.2 and 3.6 μg/ml, respectively, are predicted at steady-state.
In a study comparing the safety and efficacy of levofloxacin to that of azithromycin or ceftriaxone in 712 children with community-acquired pneumonia, serious adverse events were experienced by 6% of those treated with levofloxacin and 4% of those treated with comparator antibiotics. Most of these were considered by the treating physician to be ...
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