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Since amiodarone can be expressed in breast milk, women taking the drug are advised to stop nursing. It is contraindicated in individuals with sinus nodal bradycardia , atrioventricular block, and second or third-degree heart block who do not have an artificial pacemaker .
Amiodarone is also safe to use in individuals with cardiomyopathy and atrial fibrillation, to maintain normal sinus rhythm. Amiodarone prolongation of the action potential is uniform over a wide range of heart rates, so this drug does not have reverse use-dependent action. Amiodarone was the first agent described in this class. [4]
In pharmacokinetics, a loading dose is an initial higher dose of a drug that may be given at the beginning of a course of treatment before dropping down to a lower maintenance dose. [ 1 ] A loading dose is most useful for drugs that are eliminated from the body relatively slowly, i.e. have a long systemic half-life .
The ED50 is commonly used as a measure of the reasonable expectancy of a drug effect, but does not necessarily represent the dose that a clinician might use. This depends on the need for the effect, and also the toxicity. The toxicity and even the lethality of a drug can be quantified by the TD 50 and LD 50 respectively. Ideally, the effective ...
2. $2,000 cap on out-of-pocket prescription drug costs. In happier news, President Joe Biden passed a law limiting out-of-pocket prescription drug costs to just $2,000 annually for Medicare ...
It’s so powerful, in fact, the Food and Drug Administration allows food manufacturers to claim that consuming 3 grams of beta-glucan daily may reduce coronary heart disease risk. If you’re ...
Compounds that prolong the action potential: matching the modern classification, with the key drug example being amiodarone, and a surgical example being thyroidectomy. This was not a defining characteristic in an earlier review by Charlier et al. (1968), [17] but was supported by experimental data presented by Vaughan Williams (1970).
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