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Expressed mostly in neurons (where it is believed to be the main glucose transporter isoform), and in the placenta. Is a high-affinity isoform, allowing it to transport even in times of low glucose concentrations. GLUT4: Expressed in adipose tissues and striated muscle (skeletal muscle and cardiac muscle). Is the insulin-regulated glucose ...
GLUT4 has a Km value for glucose of about 5 mM, which as stated above is the normal blood glucose level in healthy individuals. GLUT4 is the most abundant glucose transporter in skeletal muscle and is thus considered to be rate limiting for glucose uptake and metabolism in resting muscles. [8]
n/a Ensembl n/a n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) n/a n/a PubMed search n/a n/a Wikidata View/Edit Human Glucose transporter 1 (or GLUT1), also known as solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), is a uniporter protein that in humans is encoded by the SLC2A1 gene. GLUT1 facilitates the transport of glucose across ...
SLC5A4, also known as SGLT3, is a member of the sodium-glucose cotransporter family. Unlike SGLT1 and SGLT2, which are efficient glucose transporters, SGLT3 functions primarily as a glucose sensor rather than a transporter. It has a low affinity for glucose and does not significantly contribute to glucose transport across cell membranes.
170441 Ensembl ENSG00000197496 ENSMUSG00000027661 UniProt O95528 Q8VHD6 RefSeq (mRNA) NM_030777 NM_130451 RefSeq (protein) NP_110404 NP_569718 Location (UCSC) Chr 20: 46.71 – 46.74 Mb Chr 2: 165.35 – 165.36 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Solute carrier family 2, facilitated glucose transporter member 10 is a protein that in humans is encoded by the SLC2A10 gene ...
Solute carrier family 2 (facilitated glucose transporter), member 14 is a protein that in humans is encoded by the SLC2A14 gene. [ 5 ] Members of the glucose transporter (GLUT) family, including SLC2A14, are highly conserved integral membrane proteins that transport hexoses such as glucose and fructose into all mammalian cells .
GLUT8, when expressed in Xenopus oocytes, mediates glucose uptake with high affinity. Other hexoses are not good substrates of the transporter. Mice devoid of both copies of the SLC2A8 gene are viable, fertile and do not show any obvious phenotype. [7] They are not diabetic, showing that GLUT8 is unlikely to play major roles in glucose homeostasis.
Solute carrier family 2, facilitated glucose transporter member 7 also known as glucose transporter 7 (GLUT7) is a protein that in humans is encoded by the SLC2A7 gene. [ 5 ] [ 6 ] SLC2A7 belongs to a family of transporters that catalyze the uptake of sugars through facilitated diffusion. [ 6 ]