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Hydrogel dressing is a medical dressing based on hydrogels, three-dimensional hydrophilic structure. [1] The insoluble hydrophilic structures absorb polar wound exudates and allow oxygen diffusion at the wound bed to accelerate healing. [2]
Manganese superoxide dismutase (MnSOD) is the principal antioxidant in mitochondria. Several enzymes activated by manganese contribute to the metabolism of carbohydrates, amino acids, and cholesterol. [2] A deficiency of manganese causes skeletal deformation in animals and inhibits the production of collagen in wound healing. [3]
The gel may be designed to drain, or to remain within the structure of the adhesive matrix. [4] The moist conditions produced under the dressing are intended to promote fibrinolysis, angiogenesis and wound healing, without causing softening and breaking down of tissue. The gel which is formed as a result of the absorption of wound exudate is ...
It contains gel forming agents such as carboxymethylcellulose, gelatin and pectin. When the dressing is in contact with the wound, the wound discharge are retained to form gel which provides moist environment for wound healing. It protects the wound from bacterial contamination, absorbs wound discharge, and digests necrotic tissues.
Traumagel is an algae-derived gel that comes in a pre-filled syringe and requires no manual pressure on the wound to create a blood clot, according to the company.
Nanogels are a promising technology being explored to aid in the wound healing process. [44] Given their ability to encapsulate various types of cargo, nanogels can strategically deliver anti-inflammatory agents, antimicrobial drugs, and necessary growth factors to facilitate new tissue growth and blood vessel formation. [ 44 ]