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Infective endocarditis may also be classified as culture-positive or culture-negative. By far the most common cause of "culture-negative" endocarditis is prior administration of antibiotics and can occur in up to 31% of cases. [14] [7]
The HACEK organisms are a group of fastidious Gram-negative bacteria that are an unusual cause of infective endocarditis, which is an inflammation of the heart due to bacterial infection. [1] HACEK is an abbreviation of the initials of the genera of this group of bacteria: Haemophilus , Aggregatibacter (previously Actinobacillus ...
It can also cause infections in insulin-dependent diabetics and intravenous drug users who lick their needles ("needle-licker's osteomyelitis"). [12] It is one of the HACEK group of infections which are a cause of culture-negative endocarditis. In general, the HACEK organisms are responsible for approximately 3% of all cases of infective ...
Endocarditis is an inflammation of the inner layer of the heart, the endocardium.It usually involves the heart valves.Other structures that may be involved include the interventricular septum, the chordae tendineae, the mural endocardium, or the surfaces of intracardiac devices.
Fastidious Gram-negative bacteria such as Cardiobacterium hominis along with Eikenella corrodens and Kingella kingae mainly inhabiting in the oral and upper respiratory tract in humans are responsible for 1–3% of infective endocarditis. [18] Treatment of the disease involves third-generation cephalosporin with more than 80-90% success rate. [18]
Streptococcus sanguinis, closely related to S. mutans and also found in the oral cavity, has been shown to cause Infective Endocarditis. [33] Streptococcus mutans has been associated with bacteraemia and infective endocarditis (IE). IE is divided into acute and subacute forms, and the bacterium is isolated in subacute cases.
Coxsackie B infections usually do not cause serious disease, although for newborns in the first 1–2 weeks of life, Coxsackie B infections can easily be fatal. [2] The pancreas is a frequent target, which can cause pancreatitis. [2] Coxsackie B3 (CB3) infections are the most common enterovirus cause of myocarditis and sudden cardiac death. [8]
Group A streptococcal infections are a number of infections with Streptococcus pyogenes, a group A streptococcus (GAS). [1] S. pyogenes is a species of beta-hemolytic Gram-positive bacteria that is responsible for a wide range of infections that are mostly common and fairly mild.