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  2. Noradrenergic and specific serotonergic antidepressant

    en.wikipedia.org/wiki/Noradrenergic_and_specific...

    Noradrenergic and specific serotonergic antidepressants (NaSSAs) are a class of psychiatric drugs used primarily as antidepressants. [1] They act by antagonizing the α 2 -adrenergic receptor and certain serotonin receptors such as 5-HT 2A and 5-HT 2C , [ 1 ] but also 5-HT 3 , [ 1 ] 5-HT 6 , and/or 5-HT 7 in some cases.

  3. Mirtazapine - Wikipedia

    en.wikipedia.org/wiki/Mirtazapine

    A 2012 review focused on antidepressants and sleep found that mirtazapine reduced the time it took to fall asleep and improved the quality of sleep in many people with sleep disorders caused by depression, but that it could also disturb sleep in many people, especially at higher doses, causing restless leg syndrome in 8 to 28% of people and in ...

  4. Selective serotonin reuptake inhibitor - Wikipedia

    en.wikipedia.org/wiki/Selective_serotonin...

    A 2006 review suggests that the widespread use of antidepressants in the new "SSRI-era" appears to have led to a highly significant decline in suicide rates in most countries with traditionally high baseline suicide rates. The decline is particularly striking for women who, compared with men, seek more help for depression.

  5. Serotonin–norepinephrine reuptake inhibitor - Wikipedia

    en.wikipedia.org/wiki/Serotonin–norepinephrine...

    Fluoxetine and Escitalopram are the only antidepressants that are approved for child/adolescent major depressive disorder. [96] A literature review by Castagna, et. al from 2023 shows indications of efficacy treating pediatric generalized anxiety disorder.

  6. Desipramine - Wikipedia

    en.wikipedia.org/wiki/Desipramine

    Desipramine, sold under the brand name Norpramin among others, is a tricyclic antidepressant (TCA) used in the treatment of depression. [8] It acts as a relatively selective norepinephrine reuptake inhibitor, though it does also have other activities such as weak serotonin reuptake inhibitory, α 1-blocking, antihistamine, and anticholinergic effects.

  7. A study led by the National Institute of Mental Health in Bethesda, Maryland, has now found that practising mindfulness-based stress reduction may be as effective as escitalopram (Lexapro — an ...

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