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Caspase deficiency has been identified as a cause of tumor development. Tumor growth can occur by a combination of factors, including a mutation in a cell cycle gene which removes the restraints on cell growth, combined with mutations in apoptotic proteins such as caspases that would respond by inducing cell death in abnormally growing cells. [5]
Caspase Dronc is a Drosophila melanogaster protein codified by the Dronc gene. It belongs to the cysteine-aspartic proteases family, as it is a protease enzyme that takes part in programmed cell death processes.
A set of recommendations for describing the terminology of cell death was proposed by the Nomenclature Committee on Cell Death (NCCD) in 2009, because misusing words and concepts may slow down progress in the area of cell death research. [1] The classic definition of death defines it as a state characterized by the cessation of signs of life.
Caspase-9 is an enzyme that in humans is encoded by the CASP9 gene.It is an initiator caspase, [5] critical to the apoptotic pathway found in many tissues. [6] Caspase-9 homologs have been identified in all mammals for which they are known to exist, such as Mus musculus and Pan troglodytes.
Caspase-2 is an important enzyme in the cysteine aspartate protease family, known as caspases, which are central to the regulation of apoptosis and, in certain cases, inflammation. While many caspases are mainly involved in the initiation and execution of cell death, caspase-2 has a broader range of functions.
The death-inducing signaling complex (DISC) is a multi-protein complex formed by members of the death receptor family of apoptosis-inducing cellular receptors. [1] A typical example is FasR, which forms the DISC upon trimerization as a result of its ligand binding. The DISC is composed of the death receptor, FADD, and caspase 8. It transduces a ...
Caspase 13; Caspase 14; Caspase-9; D. Death regulator Nedd2-like caspase This page was last edited on 26 January 2023, at 02:33 (UTC). Text is available under ...
Caspase 2 has a similar amino acid sequence to initiator caspases, including caspase 1, caspase 4, caspase 5, and caspase 9. It is produced as a zymogen, which contains a long pro-domain that is similar to that of caspase 9 and contains a protein interaction domain known as a CARD domain. Pro-caspase-2 contains two subunits, p19 and p12.