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Interventions can be direct (e.g. medication) or indirect (e.g. change in the process of health care like integration care by different specialists). Some definitions of health outcomes measurement stipulate that the population or group has to be defined (different outcomes are expected for different people & conditions).
Composite measures or combined measures are common in clinical research. [1] [2] The rationale is that combining different outcome measures gives greater statistical power. For example, the composite measure "Killed or Seriously Injured" is often used in studies of road safety. While deaths are easier to count and are an outcome of undisputed ...
Valderas JM, Alonso J. Patient reported outcome measures: a model-based classification system for research and clinical practice. Qual Life Res. 2008; 17: 1125–35. Wiklund I., Assessment of patient-reported outcomes in clinical trials: the example of health-related quality of life, Fundam Clin Pharmacol. 2004 Jun;18(3):351-63.
Clinical endpoints or clinical outcomes are outcome measures referring to occurrence of disease, symptom, sign or laboratory abnormality constituting a target outcome in clinical research trials. The term may also refer to any disease or sign that strongly motivates withdrawal of an individual or entity from the trial, then often termed a ...
For example, systemic lupus erythematosus (SLE) is a condition with significant morbidity and mortality and substantial disparities in outcomes among rheumatic diseases. The propensity for SLE care to be fragmented and poorly coordinated, as well as evidence that healthcare system factors associated with improved SLE outcomes are modifiable ...
The Patient-Reported Outcomes Measurement Information System [1] (PROMIS) provides clinicians and researchers access to reliable, valid, and flexible measures of health status that assess physical, mental, and social well–being from the patient perspective. PROMIS measures are standardized, allowing for assessment of many patient-reported ...
Improper reporting of health related outcomes: Many hospitals/healthcare providers do not properly report outcomes creating bias in studies. Lack of interpretability of measures/incorporation into clinical practice: Clinicians must be educated about the usefulness of outcome measures, and outcome measures must be easy to include into daily ...
Core outcome sets are commonly used by clinical investigators who conduct clinical trials for the treatment of a health condition. [2] [3] [4] The patient population associated with a particular core outcome set may vary, as some apply to all patients with that health condition and others apply to a small subset of that population. [2]
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