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Kief (from Arabic كيف kīf, "Joy, pleasure" [1] [2]), sometimes transliterated as keef, also known as "Dust" and "Chief" a.k.a cannabis crystals among other names, refers to the pure and clean collection of loose cannabis trichomes, which are accumulated by being sifted from cannabis flowers or buds with a mesh screen or sieve.
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Cannabinoids (/ k ə ˈ n æ b ə n ɔɪ d z ˌ ˈ k æ n ə b ə n ɔɪ d z /) are compounds found in the cannabis plant or synthetic compounds that can interact with the endocannabinoid system. [1] [2] The most notable cannabinoid is the phytocannabinoid tetrahydrocannabinol (THC) (Delta-9-THC), the primary intoxicating compound in cannabis.
Flower bud of a Capsicum pubescens plant, with many trichomes Fossil stellate hair (trichome) probably of an oak, in Baltic amber; image is about 1 millimetre (1 ⁄ 32 inch) wide. Trichomes (/ ˈ t r aɪ k oʊ m z, ˈ t r ɪ k oʊ m z /; from Ancient Greek τρίχωμα (tríkhōma) ' hair ') are fine outgrowths or appendages on plants, algae ...
CBN was the first cannabis compound to be isolated from cannabis extract in the late 1800s. Its structure and chemical synthesis were achieved by 1940 [ 34 ] , followed by some of the first pre-clinical research studies to determine the effects of individual cannabis-derived compounds in vivo . [ 35 ]
However, due to first-pass metabolism in the liver and the high lipid solubility of THC, only about 5 to 20% reaches circulation. [3] [22] Following oral administration, concentrations of THC and its major active metabolite 11-hydroxy-THC (11-OH-THC) peak after 0.5 to 4 hours, with median time to peak of 1.0 to 2.5 hours at different doses.
Hashish is a cannabis concentrate product composed of compressed or purified preparations of stalked resin glands, called trichomes, from the plant. It is defined by the 1961 UN Single Convention on Narcotic Drugs (Schedule I and IV) as "the separated resin, whether crude or purified, obtained from the cannabis plant".
[9] [10] Inside the transcriptomes of glandular trichomes in the cannabis plant, the pathway for cannabinoid production takes place. [9] Beginning with the formation of 3,5,7-trioxododecaneoyl-COA by the condensation reaction between hexanoyl-CoA and malonyl-CoA , catalyzed by type III polyketide synthase (PKS), the product is then used to form ...