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In the absence of an action potential, acetylcholine vesicles spontaneously leak into the neuromuscular junction and cause very small depolarizations in the postsynaptic membrane. This small response (~0.4mV) [1] is called a miniature end plate potential (MEPP) and is generated by one acetylcholine-containing vesicle. It represents the smallest ...
One quantum generates a miniature end plate potential (MEPP) which is the smallest amount of stimulation that one neuron can send to another neuron. [1] Quantal release is the mechanism by which most traditional endogenous neurotransmitters are transmitted throughout the body. The aggregate sum of many MEPPs is an end plate potential (EPP).
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The acetylcholine that reaches the endplate activates ~2,000 acetylcholine receptors, opening their ion channels which permits sodium ions to move into the endplate producing a depolarization of ~0.5 mV known as a miniature endplate potential (MEPP).
Miniature endplate potentials, spontaneous fluctuations in neuron potentials [1] 10 −3: 1–2 mV Potential created at ambient temperatures from K Type Thermocouple: Centi-10 −2 ~10–50 mV Ripple voltage in the output of a good DC power supply [9] 75 mV Nerve cell resting potential [10] Deci-10 −1: 320 mV
In neuroscience, an excitatory postsynaptic potential (EPSP) is a postsynaptic potential that makes the postsynaptic neuron more likely to fire an action potential. This temporary depolarization of postsynaptic membrane potential , caused by the flow of positively charged ions into the postsynaptic cell, is a result of opening ligand-gated ion ...
These spikes in potential are similar to action potentials except that they are much smaller, typically less than 1 mV; they were thus called miniature end plate potentials (MEPPs). In 1954, the introduction of the first electron microscopic images of postsynaptic terminals revealed that these MEPPs were created by synaptic vesicles carrying ...
Zengel J.E. and Magleby K.L. (1981) Changes in miniature endplate potential frequency during repetitive nerve stimulation in the presence of Ca 2+, Ba 2+, and Sr 2+ at the frog neuromuscular junction. J. Gen. Physiol. 77, 503-529. Zengel J.E. and Magleby K.L. (1982) Augmentation and facilitation of transmitter release.