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  2. Clark's rule - Wikipedia

    en.wikipedia.org/wiki/Clark's_rule

    Clark's rule is a medical term referring to a mathematical formula used to calculate the proper dosage of medicine for children aged 2–17 based on the weight of the patient and the appropriate adult dose. [1] The formula was named after Cecil Belfield Clarke (1894–1970), a Barbadian physician who practiced throughout the UK, the West Indies ...

  3. 2,4-Dinitrophenol - Wikipedia

    en.wikipedia.org/wiki/2,4-Dinitrophenol

    [1] [38] Although he was aware of DNP's narrow therapeutic index, Tainter tried the drugs on obese patients and published successful results in 1933; average weight loss was 20 pounds (9.1 kg) and most recipients did not report adverse effects. In 1934, Tainter estimated that at least 100,000 people had been treated with DNP in the United ...

  4. Acceptable daily intake - Wikipedia

    en.wikipedia.org/wiki/Acceptable_Daily_Intake

    Acceptable daily intake or ADI is a measure of the amount of a specific substance (originally applied for a food additive, later also for a residue of a veterinary drug or pesticide) in food or drinking water that can be ingested (orally) daily over a lifetime without an appreciable health risk. [1]

  5. Dose (biochemistry) - Wikipedia

    en.wikipedia.org/wiki/Dose_(biochemistry)

    Prescription drug doses are often based on body weight. [3] Drugs come with a recommended dose in milligrams or micrograms per kilogram of body weight, and that is used in conjunction with the patient's age and body weight to determine a safe dose. In single-dose scenarios, the patient's body weight and the drug's recommended dose per kilogram ...

  6. Loading dose - Wikipedia

    en.wikipedia.org/wiki/Loading_dose

    In pharmacokinetics, a loading dose is an initial higher dose of a drug that may be given at the beginning of a course of treatment before dropping down to a lower maintenance dose. [1] A loading dose is most useful for drugs that are eliminated from the body relatively slowly, i.e. have a long systemic half-life.

  7. Paraquat - Wikipedia

    en.wikipedia.org/wiki/Paraquat

    This salt is one of the most widely used herbicides worldwide. [6] It is quick-acting and non-selective, killing green plant tissue on contact. Paraquat is toxic (lethal) to human beings and animals. Paraquat's poisoning and lethality depends on the dose and how the herbicide is absorbed by the body.

  8. What Is the Maximum Dose of Ozempic for Weight Loss ... - AOL

    www.aol.com/lifestyle/maximum-dose-ozempic...

    TL;DR: "The 'right' dose is the dose that is both maximally tolerated and achieves individualized patient’s goals for good sugar and weight control," Dr. Shenoy says.

  9. Reference dose - Wikipedia

    en.wikipedia.org/wiki/Reference_dose

    A reference dose is the United States Environmental Protection Agency's maximum acceptable oral dose of a toxic substance, "below which no adverse noncancer health effects should result from a lifetime of exposure". Reference doses have been most commonly determined for pesticides. The EPA defines an oral reference dose (abbreviated RfD) as: