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The system is based on LD50 determination in rats, thus an oral solid agent with an LD50 at 5 mg or less/kg bodyweight is Class Ia, at 5–50 mg/kg is Class Ib, LD50 at 50–2000 mg/kg is Class II, and at LD50 at the concentration more than 2000 mg/kg is classified as Class III. Values may differ for liquid oral agents and dermal agents. [1]
A particularly efficient form of pesticide dose transfer is seed treatment and specific formulations have been developed for this purpose. A number of pesticide bait formulations are available for rodent pest control, etc.
The median effective dose is the dose that produces a quantal effect (all or nothing) in 50% of the population that takes it (median referring to the 50% population base). [6] It is also sometimes abbreviated as the ED 50, meaning "effective dose for 50% of the population". The ED50 is commonly used as a measure of the reasonable expectancy of ...
A reference dose is the United States Environmental Protection Agency's maximum acceptable oral dose of a toxic substance, "below which no adverse noncancer health effects should result from a lifetime of exposure". Reference doses have been most commonly determined for pesticides. The EPA defines an oral reference dose (abbreviated RfD) as:
The Hierarchy of Occupational Exposure Limits, of which occupational exposure banding is a member. Occupational exposure banding, also known as hazard banding, is a process intended to quickly and accurately assign chemicals into specific categories (bands), each corresponding to a range of exposure concentrations designed to protect worker health.
The EC 50 of a quantal dose response curve represents the concentration of a compound where 50% of the population exhibit a response, [5] after a specified exposure duration. For clarification, a graded dose response curve shows the graded effect of the drug (y axis) over the dose of the drug (x axis) in one or an average of subjects.
A manual backpack-type sprayer Space treatment against mosquitoes using a thermal fogger Grubbs Vocational College students spraying Irish potatoes. Pesticide application is the practical way in which pesticides (including herbicides, fungicides, insecticides, or nematode control agents) are delivered to their biological targets (e.g. pest organism, crop or other plant).
This salt is one of the most widely used herbicides worldwide. [6] It is quick-acting and non-selective, killing green plant tissue on contact. Paraquat is toxic (lethal) to human beings and animals. Paraquat's poisoning and lethality depends on the dose and how the herbicide is absorbed by the body.