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The H 2 receptor antagonists are a class of drugs used to block the action of histamine on parietal cells in the stomach, decreasing the production of acid by these cells. H 2 antagonists are used in the treatment of dyspepsia, although they have been surpassed in popularity by the more effective [1] proton pump inhibitors.
The proton pump is the terminal stage in gastric acid secretion, being directly responsible for secreting H + ions into the gastric lumen, making it an ideal target for inhibiting acid secretion. [ citation needed ] Because the H,K-ATPase is the final step of acid secretion, an inhibitor of this enzyme is more effective than receptor ...
Proton pump inhibitors (PPIs) block the gastric hydrogen potassium ATPase (H + /K + ATPase) and inhibit gastric acid secretion. These drugs have emerged as the treatment of choice for acid-related diseases, including gastroesophageal reflux disease (GERD) and peptic ulcer disease. PPIs also can bind to other types of proton pumps such as those ...
Antacids, H2 blockers (which work to reduce stomach acid), and proton pump inhibitors (PPIs) may provide relief from acid reflux symptoms. However, always consult a healthcare professional before ...
Omeprazole is a selective and irreversible proton pump inhibitor. It suppresses stomach acid secretion by specific inhibition of the H + /K +-ATPase system found at the secretory surface of gastric parietal cells. Because this enzyme system is regarded as the acid (proton, or H +) pump within the gastric mucosa, omeprazole inhibits the final ...
Pantoprazole is a proton pump inhibitor that decreases gastric acid secretion. [8] It works by inactivating (H+/K+)-ATPase function in the stomach. [12] [8] The study of pantoprazole began in 1985, and it came into medical use in Germany in 1994. [13] It is available as a generic medication.
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