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People suffering from 6PGD or G6PD deficiency (or both) are at risk of hemolytic anemia in states of oxidative stress. Oxidative stress can result from infection and from chemical exposure to medication and certain foods. Broad beans, e.g., fava beans, contain high levels of vicine, divicine, convicine and isouramil, all of which are oxidants.
Most individuals with G6PD deficiency are asymptomatic.When it induces hemolysis, the effect is usually short-lived. [5]Most people who develop symptoms are male, due to the X-linked pattern of inheritance, but female carriers can be affected due to unfavorable lyonization or skewed X-inactivation, where random inactivation of an X-chromosome in certain cells creates a population of G6PD ...
G6PD converts G6P into 6-phosphoglucono-δ-lactone and is the rate-limiting enzyme of the pentose phosphate pathway. Thus, regulation of G6PD has downstream consequences for the activity of the rest of the pentose phosphate pathway. Glucose-6-phosphate dehydrogenase is stimulated by its substrate G6P.
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G6PD deficient red cells in combination with high levels of oxidants causes a cross-linking of sulfhydryl groups on globin chains which causes a denaturing and formation of Heinz body precipitates. [8] Heinz bodies can also be found in chronic liver disease. [9] Alpha-thalassemia. Normal adult hemoglobin is composed of two alpha and two beta ...
The Centre of the People's Power (Indonesian: Pusat Tenaga Rakyat, Putera) was a propaganda organization established by the Empire of Japan during their occupation of the Dutch East Indies.
The Indonesia Futsal Federation (Indonesian: Federasi Futsal Indonesia; abbreviated as FFI) is the governing body of futsal in Indonesia and a member association of Indonesia's football governing body, PSSI.