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Scorpion toxins are proteins found in the venom of scorpions.Their toxic effect may be mammal- or insect-specific and acts by binding with varying degrees of specificity to members of the Voltage-gated ion channel superfamily; specifically, voltage-gated sodium channels, voltage-gated potassium channels, [3] and Transient Receptor Potential (TRP) channels.
The crude venom of T. serrulatus contains different toxins. Some of the strongest derivates are the neurotoxins tityustoxin and toxin Ts-g. [3] Two types of toxins are considered to be responsible for the main toxic effect: toxin gamma (a β-type toxin) and tityustoxin (TsTX, an α-type toxin), both with a specific affinity to the sodium channel. [4]
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NTX accounts for only about 1% of the scorpion venom. [7] NTX is one of the best-studied toxic peptides from scorpion venoms . [ 6 ] It was the second purified toxin obtained from the genus Centruroides after neurotoxin II [ 8 ] and the first short peptide from scorpion venom to be reported in the literature. [ 9 ]
Scorpion venom is a mixture of neurotoxins; most of these are peptides, chains of amino acids. [114] Many of them interfere with membrane channels that transport sodium, potassium, calcium, or chloride ions. These channels are essential for nerve conduction, muscle contraction and many other biological processes. Some of these molecules may be ...
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Of more than a thousand known species of scorpion, only a few dozen have venom that is dangerous to humans, [6] most notably the bark scorpions, including: Centruroides spp. Deathstalker (Leiurus quinquestriatus) Central and South American Tityus, include the Brazilian yellow scorpion. Androctonus spp. Parabuthus spp. Hottentotta spp.
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