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HRG is a glycoprotein of 70-75kDa present at a relatively high concentration in the plasma of vertebrates.The primary structure of human HRG is predicted to be a 507 amino acid multidomain polypeptide consisting of two cystatin-like regions at the N-terminus, a histidine-rich region (HRR) flanked by proline-rich regions (PRR), and a C-terminal domain. [10]
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Glycoprotein size and composition can vary largely, with carbohydrate composition ranges from 1% to 70% of the total mass of the glycoprotein. [4] Within the cell, they appear in the blood, the extracellular matrix , or on the outer surface of the plasma membrane, and make up a large portion of the proteins secreted by eukaryotic cells. [ 4 ]
Histidine ball and stick model spinning. Histidine (symbol His or H) [2] is an essential amino acid that is used in the biosynthesis of proteins.It contains an α-amino group (which is in the protonated –NH 3 + form under biological conditions), a carboxylic acid group (which is in the deprotonated –COO − form under biological conditions), and an imidazole side chain (which is partially ...
The function of Fetuin-A in the body was determined by gene knockout technology in mice. Knocking out the gene for fetuin-A rendered the mice completely fetuin-A deficient. Feeding a mineral-rich diet to fetuin-A-deficient mice resulted in widespread calcification (ectopic mineralization) of lung, heart, and kidneys in these mice. The ...
n/a Ensembl ENSG00000143631 n/a UniProt P20930 n/a RefSeq (mRNA) NM_002016 n/a RefSeq (protein) NP_002007 n/a Location (UCSC) Chr 1: 152.3 – 152.33 Mb n/a PubMed search n/a Wikidata View/Edit Human Filaggrin (fil ament aggr egating prote in) is a filament-associated protein that binds to keratin fibers in epithelial cells. Ten to twelve filaggrin units are post-translationally hydrolyzed ...
n/a Ensembl ENSG00000130528 n/a UniProt P23327 n/a RefSeq (mRNA) NM_002152 n/a RefSeq (protein) NP_002143 n/a Location (UCSC) Chr 19: 49.15 – 49.16 Mb n/a PubMed search n/a Wikidata View/Edit Human Sarcoplasmic reticulum histidine-rich calcium-binding protein is a protein that in humans is encoded by the HRC gene. Function Histidine-rich calcium-binding protein is a luminal sarcoplasmic ...
n/a Ensembl ENSG00000205649 ENSG00000282967 n/a UniProt P15516 n/a RefSeq (mRNA) NM_000200 n/a RefSeq (protein) NP_000191 n/a Location (UCSC) Chr 4: 70.03 – 70.04 Mb n/a PubMed search n/a Wikidata View/Edit Human Histatin 3, also known as HTN3, is a protein which in humans is encoded by the HTN3 gene. Function The primary protein encoded by HTN3 is histatin 3. Histatins are a family of small ...