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Total iron-binding capacity (TIBC) or sometimes transferrin iron-binding capacity is a medical laboratory test that measures the blood's capacity to bind iron with transferrin. [1] Transferrin can bind two atoms of ferric iron (Fe 3+ ) with high affinity.
Studies reveal that a transferrin saturation (serum iron concentration ÷ total iron binding capacity) over 60 percent in men and over 50 percent in women identified the presence of an abnormality in iron metabolism (hereditary hemochromatosis, heterozygotes, and homozygotes) with approximately 95 percent accuracy. This finding helps in the ...
In iron deficiency anemia (IDA) ferritin is low. [6] Total iron-binding capacity is high in iron deficiency, reflecting production of more transferrin to increase iron binding; TIBC is low or normal in anemia of chronic inflammation.
The World Health Organization defines low ferritin in adults as below 15 nanograms per milliliter, but in clinical practice, iron deficiency may be diagnosed when ferritin is below 30 nanograms ...
Normal total iron-binding capacity for both sexes is 240 to 450 μg/dL. [6] Total iron-binding capacity increases when iron deficiency exists. [4] Serum ferritin levels reflect the iron stores available in the body. [4] The normal range is 20 to 200 nanograms per milliliter (ng/mL) for men and 15 to 150 ng/mL for women. [8] Low levels (< 12 ng ...
It is the value of serum iron divided by the total iron-binding capacity [1] of the available transferrin, the main protein that binds iron in the blood, this value tells a clinician how much serum iron is bound. For instance, a value of 15% means that 15% of iron-binding sites of transferrin are being occupied by iron.
A complete blood count can reveal microcytic anemia, [25] although this is not always present – even when iron deficiency progresses to iron-deficiency anemia. Low serum ferritin (see below) Low serum iron; High TIBC (total iron binding capacity), although this can be elevated in cases of anemia of chronic inflammation.
Transferrin saturation of greater than 45% combined with an elevated ferritin level is highly sensitive in diagnosing HFE hemochromatosis. [7] Total iron binding capacity may be low in hemochromatosis, but can also be normal. [37]