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Cholera (/ ˈ k ɒ l ər ə /) is an infection of the small intestine by some strains of the bacterium Vibrio cholerae. [4] [3] Symptoms may range from none, to mild, to severe. [3]The classic symptom is large amounts of watery diarrhea lasting a few days. [2]
Cholera infections are most commonly acquired from drinking water in which V. cholerae is found naturally or into which it has been introduced from the feces of an infected person. Cholera is most likely to be found and spread in places with inadequate water treatment, poor sanitation, and inadequate hygiene.
A cholera vaccine is a vaccine that is effective at reducing the risk of contracting cholera. [10] The recommended cholera vaccines are administered orally to elicit local immune responses in the gut, where the intestinal cells produce antibodies against Vibrio cholerae, the bacteria responsible for the illness. This immune response was poorly ...
The following outline is provided as an overview of and topical guide to concepts related to infectious diseases in humans.. Infection – transmission, entry/invasion after evading/overcoming defense, establishment, and replication of disease-causing microscopic organisms (pathogens) inside a host organism, and the reaction of host tissues to them and to the toxins they produce.
Indian Council of Medical Research (ICMR) set up a cholera research centre at Kyd Street, Kolkata, West Bengal. [5] The aim of establishing this centre was to conduct research related to cholera and other enteric diseases. In 1979, the cholera research centre was renamed to National Institute of Cholera and Enteric Diseases (NICED).
The most common cause is an infection of the intestines due to a virus, bacterium, or parasite—a condition also known as gastroenteritis. [2] These infections are often acquired from food or water that has been contaminated by feces, or directly from another person who is infected. [2]
Rifaximin and rifamycin are approved in the U.S. for treatment of TD caused by ETEC. [38] [39] If diarrhea persists despite therapy, travelers should be evaluated for bacterial strains resistant to the prescribed antibiotic, possible viral or parasitic infections, [12] bacterial or amoebic dysentery, Giardia, helminths, or cholera. [13]
Cholera toxin mechanism. Cholera toxin (also known as choleragen and sometimes abbreviated to CTX, Ctx or CT) is an AB5 multimeric protein complex secreted by the bacterium Vibrio cholerae. [1] [2] CTX is responsible for the massive, watery diarrhea characteristic of cholera infection. [3] It is a member of the heat-labile enterotoxin family.