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The patients cannula are attached to an ECMO circuit with blood flow targets of 3Lmin −1 and oxygen blood flow of 3L min −1 commenced. An arterial blood gas is used to assess for successful oxygenation and metabolic improvement following the commencement of ECMO.
Reperfusion therapy is a medical treatment to restore blood flow, either through or around, blocked arteries, typically after a heart attack (myocardial infarction (MI)). Reperfusion therapy includes drugs and surgery. The drugs are thrombolytics and fibrinolytics used in a process called thrombolysis.
ECMO should be performed only by clinicians with training and experience in its initiation, maintenance, and discontinuation. ECMO insertion is typically performed in the operating room setting by a cardiothoracic surgeon. ECMO management is commonly performed by a registered nurse, respiratory therapist, or a perfusionist.
The main reason for the acute phase of ischemia-reperfusion injury is oxygen deprivation and, therefore, arrest of generation of ATP (cellular energy currency) by mitochondria oxidative phosphorylation. Tissue damage due to the general energy deficit during ischemia is followed by reperfusion (increase of oxygen level) when the injury is enhanced.
In the Lund protocol, the main procedures involve reconditioning and assessment. During the reconditioning phase, various measures are taken to improve lung function. This includes recruiting atelectasis –partial collapses of the lungs, controlling inflammation using a leukocyte filter, circulating antimicrobials and glucocorticoids during ...
Following the bidirectional Glenn shunt, failure of the procedure can be broadly categorized as failure of procedure, cardiac dysfunction related to surgery, or cardiac dysfunction leading to death before further surgical intervention. [8] Retrospective reviews demonstrate failure of the procedure in 6.5% of patients.
A procedure in which blood is taken from a patient's circulation to have a process applied to it before it is returned to the circulation. All of the apparatuses carrying the blood outside the body are collectively termed the extracorporeal circuit. Intra-surgical cell salvage (aspiration, washing and Autotransfusion) Apheresis
Remote ischemic conditioning (RIC) is an experimental medical procedure that aims to reduce the severity of ischaemic injury to an organ such as the heart or the brain, most commonly in the situation of a heart attack or a stroke, or during procedures such as heart surgery when the heart may temporary suffer ischaemia during the operation, by triggering the body's natural protection against ...