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Degenerative disease is the result of a continuous process based on degenerative cell changes, affecting tissues or organs, which will increasingly deteriorate over time. [ 1 ] In neurodegenerative diseases , cells of the central nervous system stop working or die via neurodegeneration .
Alzheimer's disease (AD) is a chronic neurodegenerative disease that results in the loss of neurons and synapses in the cerebral cortex and certain subcortical structures, resulting in gross atrophy of the temporal lobe, parietal lobe, and parts of the frontal cortex and cingulate gyrus. [14] It is the most common neurodegenerative disease. [1]
Degeneration is deterioration in the medical sense. Generally, it is the change from a higher to a lower form. Generally, it is the change from a higher to a lower form. More specifically, it is the change of tissue to a lower or less functionally active form.
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[7] [8] [9] It has been proposed that age-related diseases are mediated by vicious cycles. [10] On the basis of extensive research, DNA damage has emerged a major culprit in cancer and numerous other diseases related to ageing. [11] DNA damage can initiate the development of cancer or other aging related diseases depending on several factors.
[1] [2] Risk is greater in those who are overweight, have legs of different lengths, or have jobs that result in high levels of joint stress. [1] [2] [8] Osteoarthritis is believed to be caused by mechanical stress on the joint and low grade inflammatory processes. [9] It develops as cartilage is lost and the underlying bone becomes affected. [1]
Myelopathy describes any neurologic deficit related to the spinal cord. [1] The most common form of myelopathy in humans, cervical spondylotic myelopathy (CSM) , [ 2 ] [ 3 ] also called degenerative cervical myelopathy , [ 4 ] results from narrowing of the spinal canal ( spinal stenosis ) ultimately causing compression of the spinal cord. [ 5 ]
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