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Daratumumab, sold under the brand name Darzalex among others, is an anti-cancer monoclonal antibody medication. It binds to CD38 , [ 7 ] which is overexpressed in multiple myeloma cells. [ 8 ]
It was approved for use in the United States in May 2020. [2] [7] [8]Efficacy of daratumumab and hyaluronidase-fihji (monotherapy) was evaluated in the COLUMBA trial (NCT03277105), an open-label non-inferiority trial randomizing 263 participants to daratumumab and hyaluronidase-fihj and 259 to intravenous daratumumab (daratumumab IV). [2]
Many patients will not develop these side effects, although there is still a significant possibility of risks associated with Antipsychotic usage. The percentage of patients affected by side effects like Tardive dyskinesia is significantly high and estimated to be a 20-50% prevalence. [1] [2]
A study confirmed that side effects like pancreatitis and kidney damage are possible while taking GLP-1s like Ozempic. Here's what a doctor wants you to know.
Common symptoms of chronic inflammation include fatigue, joint or muscle pain, long-lasting digestive issues, brain fog or difficulty concentrating, skin problems (like eczema or acne) and ...
After daratumumab treatment, both patients showed stabilization of kidney function parameters and a steep decline in dd-cfDNA levels below the clinical threshold for rejection. Biopsies six months after treatment demonstrated complete histologic resolution of AMR activity in one patient and partial resolution in the other.
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