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The first cases of CKDu were reported in Sri Lanka's North Central Province (NCP). Chronic kidney disease (listed under diseases of the urinary tract), was identified as the 8th leading cause of in-hospital mortality in Sri Lanka, and the leading cause of death in Anuradhapura and Polonnaruwa in 2016. [1]
Nephronophthisis is a genetic disorder of the kidneys which affects children. [3] It is classified as a medullary cystic kidney disease.The disorder is inherited in an autosomal recessive fashion and, although rare, is the most common genetic cause of childhood kidney failure.
Hematuria (one of the symptoms of Nephritic syndrome. Historically, nephritic syndrome has been characterized by blood in the urine (), high blood pressure (hypertension), decreased urine output <400 ml/day (), red blood cell casts, pyuria, and mild to moderate proteinuria.
Decreased urine output or kidney function may be the only observable symptoms caused by a blood clot renal vein. Other less common causes include hypercoagulable state, invasion by renal cell carcinoma, kidney transplantation, Behcet syndrome, antiphospholipid antibody syndrome or blunt trauma to the back or abdomen. [3]
One of the measures of kidney function is the glomerular filtration rate (GFR). Other tests that can assess the function of the kidneys include assessment of electrolyte levels such as potassium and phosphate, assessment of acid-base status by the measurement of bicarbonate levels from a vein, and assessment of the full blood count for anaemia.
The term "non-dialysis-dependent chronic kidney disease" (NDD-CKD) is a designation used to encompass the status of those persons with an established CKD who do not yet require the life-supporting treatments for kidney failure known as kidney replacement therapy (RRT, including maintenance dialysis or kidney transplantation).
Proper kidney function depends upon adequate blood flow to the kidney. Kidney blood flow is a complex, tightly regulated process that relies on a number of hormones and other small molecules, such as prostaglandins. Under normal circumstances, prostaglandin E2 (PGE 2) produced by the kidney is necessary to support adequate blood flow to the kidney.
Kidney failure is known as the end-stage of kidney disease, where dialysis or a kidney transplant is the only treatment option. Chronic kidney disease is defined as prolonged kidney abnormalities (functional and/or structural in nature) that last for more than three months. [ 1 ]