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Aducanumab, sold under the brand name Aduhelm, is an anti-amyloid drug designed to treat Alzheimer's disease. It is a monoclonal antibody that targets aggregated forms (plaque) of amyloid beta (Aβ) found in the brains of people with Alzheimer's disease to reduce its buildup. [10] It was developed by Biogen and Eisai. [11] Aducanumab is given via intravenous infusion. [5] Aducanumab was ...
Some plaques occur in the brain as a result of aging, but large numbers of plaques and neurofibrillary tangles are characteristic features of Alzheimer's disease. [5] The plaques are highly variable in shape and size; in tissue sections immunostained for Aβ, they comprise a log-normal size distribution curve, with an average plaque area of 400 ...
Research published in December 2022 found injecting a form of neprilysin that can penetrate the blood-brain barrier showed the potential to reduce beta-amyloid plaques in the brain. Neprilysin ...
Alzheimer’s disease develops when abnormal levels of a protein fragment called beta-amyloid build up in and around brain cells. The resulting clumps are called amyloid plaques , which may not ...
New preclinical-stage research suggests that targeting a specific protein in the brain could help clear toxic amyloid plaques typically linked to Alzheimer's disease progression.
Alzheimer's disease has been identified as a protein misfolding disease, a proteopathy, caused by the accumulation of abnormally folded amyloid beta protein into amyloid plaques, and tau protein into neurofibrillary tangles in the brain. [77] Plaques are made up of small peptides, 39–43 amino acids in length, called
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