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Sertraline, sold under the brand name Zoloft among others, is an antidepressant medication of the selective serotonin reuptake inhibitor (SSRI) class [10] used to treat major depressive disorder, generalized anxiety disorder, social anxiety disorder, obsessive–compulsive disorder (OCD), panic disorder, and premenstrual dysphoric disorder. [11]
The LUNSERS is designed to monitor medication-induced side effects. This psychiatric assessment tools allows for the monitoring of side effects related to neuroleptic (or anti-psychotic) medications. The test is a self-reported check-tick box format with a predefined scale from "not at all" to "very much".
Paroxetine was the first drug to be approved for social anxiety disorder and it is considered effective for this disorder; sertraline and fluvoxamine were later approved for it as well. Escitalopram and citalopram are used off-label with acceptable efficacy, while fluoxetine is not considered to be effective for this disorder. [ 22 ]
Serotonin. A serotonin reuptake inhibitor (SRI) is a type of drug which acts as a reuptake inhibitor of the neurotransmitter serotonin (5-hydroxytryptamine, or 5-HT) by blocking the action of the serotonin transporter (SERT).
Figure 1 Chemical structure of zimelidine. An initial success was achieved when medicinal chemists set out in search of the ideal SSRI with the chemical synthesis of zimelidine (figure 1) from the antihistamine drug brompheniramine, [8] which exhibited selective inhibition of 5-HT re-uptake with minimal inhibition of norepinephrine (NE) re
It was accepted by Andrew Lansley that a number of trusts would never reach foundation trust status, and a new organisation – the NHS Trust Development Authority – was established by the Health and Social Care Act 2012 to supervise trusts which have not reached foundation status, of which there were 99 in April 2013, 47 of which were never ...
The antidepressants taken by Thomas Kingston before he killed himself have ben flagged more than 40 times by coroners, it has been found. The 45-year-old husband of Lady Gabriella Windsor took his ...
Desmethylsertraline (DMS), also known as norsertraline, is an active metabolite of the antidepressant drug sertraline.Like sertraline, desmethylsertraline acts as a monoamine reuptake inhibitor, and may be responsible for some of its parent's therapeutic benefits; however, the effects of DMS's main activity of increasing serotonin levels via binding to the serotonin transporter appears to be ...