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Nausea and vomiting are common side effects when first beginning therapy with apomorphine; [18] antiemetics such as trimethobenzamide or domperidone, dopamine antagonists, [19] are often used while first starting apomorphine. Around 50% of people grow tolerant enough to apomorphine's emetic effects that they can discontinue the antiemetic.
Side effects in dogs and cats include hypersalivation, diarrhea, loss of appetite, and vomiting. [12] [16] Eight percent of dogs taking maropitant at doses meant to prevent motion sickness vomited right after, likely due to the local effects maropitant had on the gastrointestinal tract. Small amounts of food beforehand can prevent such post ...
apomorphine – emetic (used to induce vomiting) artificial tears – lubricant eye drops used as a tear supplement; atenolol – treats cardiac arrhythmias, hypertension, and diabetes plus other cardiovascular disorders; atipamezole – α 2-adrenergic antagonist used to reverse the sedative and analgesic effects of alpha-2 adrenergic receptor ...
Do not allow a dog to gulp large quantities of water. If a dog is panting excessively and then drinks a lot of water, large amounts of air may be swallowed along with the water and this can cause an equally life-threatening case of gastric dilatation volvulus (bloat) in the stomach. [172]
There are no studies on aporphine in animals. However, studies on subcutaneous apomorphine injection, the bioactive form of aporphine, have been carried out. In a 5-day study, mice were administered up to 10 mg/kg apomorphine subcutaneously daily. No adverse effects were observed other than a slight increase in dopamine levels. [28]
Most dogs, however, will need radiation, chemotherapy, and other medications. Even with those therapies, the survival time is short, so ivermectin could help if it proves to be useful.
Around 1970 clinicians started using the dopamine agonist apomorphine alongside L-DOPA to minimize the side effects caused by L-DOPA, the dopamine agonists bind to the dopamine receptor in the absence of dopamine. Apomorphine had limited use since it had considerable side effects and difficulty with administration.
Less-common side effects can include excess air or gas in your stomach, burping, heartburn, indigestion, fast heartbeat, low blood sugar, low energy and fatigue, or even gallstones, Dr. Comite says.