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Penile cancer is a rare cancer in developed nations, with annual incidence varying from 0.3 to 1 per 100,000 per year, accounting for around 0.4–0.6% of all malignancies. [4] The annual incidence is approximately 1 in 100,000 men in the United States, [ 28 ] 1 in 250,000 in Australia, [ 29 ] and 0.82 per 100,000 in Denmark. [ 30 ]
IARC group 2A agents are substances and exposure circumstances that have been classified as probable carcinogens by the International Agency for Research on Cancer (IARC). [1] This designation is applied when there is limited evidence of carcinogenicity in humans, as well as sufficient evidence of carcinogenicity in experimental animals .
Chloramphenicol is an antibiotic useful for the treatment of a number of bacterial infections. [5] This includes use as an eye ointment to treat conjunctivitis. [6] By mouth or by injection into a vein, it is used to treat meningitis, plague, cholera, and typhoid fever. [5]
Examples of amphenicols include chloramphenicol, thiamphenicol, azidamfenicol, and florfenicol. The first-in-class compound was chloramphenicol, introduced in 1949. Chloramphenicol was initially discovered as a natural product and isolated from the soil bacteria Streptomyces venezuelae; [2] however, all amphenicols are now made by chemical ...
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The probability of contracting a cancerous development depends on age, ethnicity and the existence, or non-existence, of environmental causation. Unlike all other genitally situated cancers, the incidence of penis cancer is related to the sexual mode of transmission. [3]
Penile cancer is due to trapped fluids under the foreskin of the penis. Uncircumcised individuals have a higher risk of penile cancer. Symptoms that may indicate penile cancer during male examination include lumps on the penis, swelling, and skin around the penis becoming thicker. Penile cancer and its grade is diagnosed by a biopsy to confirm ...
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