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2. Beta blocker - Wikipedia

   en.wikipedia.org/wiki/Beta_blocker

   Beta blockers vary in their lipophilicity (fat solubility) and in turn in their ability to cross the blood–brain barrier and exert effects in the central nervous system. [76] Beta blockers with greater blood–brain barrier permeability can have both neuropsychiatric therapeutic benefits and side effects, as well as adverse cognitive effects ...

3. Insomnia: causes, symptoms, treatments and how it affects you

   www.aol.com/lifestyle/insomnia-causes-symptoms...

   Chronic insomnia often requires more comprehensive treatment to help you address underlying causes, implement healthy sleep habits and learn techniques to manage sleep-disrupting thoughts and ...

4. Metoprolol - Wikipedia

   en.wikipedia.org/wiki/Metoprolol

   Metoprolol is classified as a moderately lipophilic beta blocker. [37] More lipophilic beta blockers tend to cross the blood–brain barrier more readily, with greater potential for effects in the central nervous system as well as associated neuropsychiatric side effects. [37] Metoprolol binds mainly to human serum albumin with an unbound ...

5. Bisoprolol - Wikipedia

   en.wikipedia.org/wiki/Bisoprolol

   Non-selective beta-blockers should be avoided in people with asthma or bronchospasm as they may cause exacerbations and worsening of symptoms. [ 27 ] [ 28 ] [ 29 ] β 1 selective beta-blockers like bisoprolol have not been shown to cause an increase in asthma exacerbations, [ 28 ] and may be cautiously tried in those with controlled, mild-to ...

6. Discovery and development of beta-blockers - Wikipedia

   en.wikipedia.org/wiki/Discovery_and_development...

   Figure 1: The chemical structure of dichloroisoprenaline or dichloroisoproterenol (), abbreviated DCI — the first β-blocker to be developed. β adrenergic receptor antagonists (also called beta-blockers or β-blockers) were initially developed in the 1960s, for the treatment of angina pectoris but are now also used for hypertension, congestive heart failure and certain arrhythmias. [1]

7. Propranolol - Wikipedia

   en.wikipedia.org/wiki/Propranolol

   While once a first-line treatment for hypertension, the role of beta blockers was downgraded in June 2006 in the United Kingdom to fourth-line, as they do not perform as well as other drugs, particularly in the elderly, and evidence is increasing that the most frequently used beta blockers at usual doses carry an unacceptable risk of provoking ...