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Exocrine pancreatic insufficiency (EPI) is the inability to properly digest food due to a lack or reduction of digestive enzymes made by the pancreas.EPI can occur in humans and is prevalent in many conditions [1] such as cystic fibrosis, [2] Shwachman–Diamond syndrome, [3] different types of pancreatitis, [4] multiple types of diabetes mellitus (Type 1 and Type 2 diabetes), [5] advanced ...
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World Health Organization (2019) Countries Life expectancy at birth HALE at birth Life expectancy at age 60 HALE at age 60 All M F FΔM Δ 2000 All M F FΔM Δ
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World Bank Group (2022) Countries and territories 2022 Historical data recovery from COVID-19: 2019→2022 All Male Female Sex gap 2014 2014 →2019
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Symptoms often include action or stimuli induced myoclonus, seizures, neuropathy, cognitive decline, and spike and wave or no cerebral discharges. [4] The prognosis of those diagnosed with PME is poor. The person often becomes reliant on a wheelchair, enters a vegetative state due to myoclonus, and has a shortened life expectancy. [4] [3]
The cause of ULD is known to be a mutation of the gene that produces cystatin B. [2] The disease is autosomal recessive, so both parents of an individual must be carriers of the recessive CSTB gene for the individual to inherit it, and for an individual to show symptoms of ULD, they must have both recessive CSTB genes. [2]