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A summary of CHOP upstream and downstream pathways. The PERK-ATF4-CHOP pathway can induce apoptosis by binding to the death receptors and upregulating the expression of death receptor 4 (DR4) and DR5. CHOP also interacts with the phosphorylated transcription factor JUN to form a complex that binds to the promoter region of DR4 in lung cancer ...
CHOP is the acronym for a chemotherapy regimen used in the treatment of non-Hodgkin lymphoma. CHOP consists of: CHOP consists of: C yclophosphamide , an alkylating agent which damages DNA by binding to it and causing the formation of cross-links
Rescue treatment involves acute symptomatic control with medication. [4] Recommendations for rescue therapy of migraine include: (1) migraine-specific agents such as triptans, CGRP antagonists, or ditans for patients with severe headaches or for headaches that respond poorly to analgesics, (2) non-oral (typically nasal or injection) route of administration for patients with vomiting, (3) avoid ...
A migraine attack lasting longer than 72 hours is termed status migrainosus. [30] There are four possible phases to a migraine attack, although not all the phases are necessarily experienced: [31] The prodrome, which occurs hours or days before the headache; The aura, which immediately precedes the headache; The pain phase, also known as ...
{{Medical cases chart |float = side of the page where the chart will be located (left|center|right|none) [optional, defaults to: right] |barwidth = width of the stacked bars area (thin|medium|wide|auto) [optional, defaults to: medium] |numwidth = max width of the numbers in the right columns (AA or AAAA)←(n|t|m|w|x|d) [suggested, defaults to: mm; see info below] |rowheight = height of each ...
Figure 1 is a causal graph that represents this model specification. Each variable in the model has a corresponding node or vertex in the graph. Additionally, for each equation, arrows are drawn from the independent variables to the dependent variables.
Status migrainosus. 3 languages. ... Text is available under the Creative Commons Attribution-ShareAlike 4.0 License; additional terms may apply.
On the other hand, ATF4 and CHOP work together to induce cell death, as well as regulating amino acid biosynthesis, transport and metabolic processes. The presence of a leucine zipper domain ( bZIP ) allows ATF4 to work together with many other proteins, thus creating specific responses to different types of stressors.