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This is generally defined by the range between the minimum effective dose (MED) and the maximum tolerated dose (MTD). The MED is defined as the lowest dose level of a pharmaceutical product that provides a clinically significant response in average efficacy, which is also statistically significantly superior to the response provided by the ...
The “minimum effective dose” of exercise refers to the smallest amount of physical activity required to achieve noticeable health benefits. “The Centers for Disease Control and Prevention ...
Median lethal dose: For either drugs or toxins, it is a toxic unit that measures the minimum dose that causes death (lethal dose) in 50% of cases. Median toxic dose: It is the minimum dose at which toxicity occurs in 50% of cases. Half maximal effective concentration
In such cases, the effective dose is the amount and frequency that produces the desired effect, which can vary, and can be greater or less than the therapeutically effective dose. The Certain Safety Factor , also referred to as the Margin of Safety (MOS) , is the ratio of the lethal dose to 1% of population to the effective dose to 99% of the ...
Effective dose is a dose quantity in the International Commission on Radiological Protection (ICRP) system of radiological protection. [1]It is the tissue-weighted sum of the equivalent doses in all specified tissues and organs of the human body and represents the stochastic health risk to the whole body, which is the probability of cancer induction and genetic effects, of low levels of ...
Effective dose or internal dose may refer to: Effective dose (pharmacology), a dose or concentration of a drug that produces a biological response; Effective dose (radiation), a measure of the stochastic effect on health risk that a radiation dose internal or external to whole or part of the body will have; In toxicology, the internal dose ...
Quantitatively, it is the ratio given by the toxic dose divided by the therapeutic dose. A protective index is the toxic dose of a drug for 50% of the population (TD 50) divided by the minimum effective dose for 50% of the population (ED 50). A high protective index is preferable to a low one: this corresponds to a situation in which one would ...
Threshold dose is the minimum dose of drug that triggers minimal detectable biological effect in an animal. [1] At extremely low doses, biological responses are absent for some of the drugs. The increase in dose above threshold dose induces an increase in the percentage of biological responses. [ 2 ]